
一、个人简介
邹汉勋,1986年出生,副教授,硕士生导师(资源与环境、生物与医药方向)。博士毕业于中国科学院大学有机化学专业,先后就职于新加坡眼科研究所和中国科学院福建物质结构研究所,2023年9月以高层次人才引进至1671金沙城线路检测环境与生物工程学院工作,入选福建省高层次人才(C类)。近年来,在《Journal of the American Chemical Society》、《Journal of Hazardous Materials》、CCS Chemistry、《Chinese Chemical Letters》和《Organic Chemistry Frontiers》等国内外高水平期刊发表论文近30篇,申请国内外专利9项;担任《南昌航空大学学报(自然科学版)》、《Advanced Functional Materials》等期刊审稿人。主持国家自然科学基金一项、福建省自然科学基金一项。
研究方向
1. 针对环境污染物识别与可视化检测的荧光探针设计与应用
2. 面向精准诊疗的有机近红外荧光探针设计与生物成像应用探索
3. 基于动态共价化学和超分子策略的智能荧光功能材料构建与性能调控
教育经历
2017.09-2020.09 中国科学院大学 博士 有机化学
2009.09-2012.06 华南理工大学 硕士 有机化学
2005.09-2009.06 青岛大学 学士 化学
科研工作经历
2023.09-至今 1671金沙城线路检测,环境与生物工程学院,副教授
2024.02-2025.01 北京化工大学,化工资源有效利用国家重点实验室,访问学者(入选福建省2024-2025年度高层次人才和青年优秀人才访学研修项目)
2016.02-2023.08 中国科学院福建物质结构研究所,结构化学国家重点实验室,助理研究员
2012.07-2016.01新加坡眼科研究所,助理研究员
联系方式:13850626070,邮箱:hanxun_zou@163.com
二、科研项目
1. 基于动态共价化学的近红外二区发光组装体构筑及调控研究,国家自然科学基金青年项目,22101283,2022-01至2024-12,30万元,已结题,主持。
2. 比率型近红外二区荧光示踪的肿瘤诊疗前药构建及其精准响应控释研究,福建省自然科学基金面上项目,2024J01883,2024-11至2027-10,10万元,在研,主持。
3. 高反应性比率型近红外二区荧光探针设计及其在肝癌诊断的应用探索,1671金沙城线路检测交叉学科专项-工科/医科,2024033,2024-07至2027-07,5万元,在研,主持。
三、科研成果
论文著作
(1) H. Zou*, G. Lin, Y. Bao, J. Liang, Y. Li, L. Cai, H.-Y. Wu, F. Yang, H. Chen, X. Lin, Y.-H. Xiao, L. Yang, J. Huang, Y. Hai*. Dual-Emission Fluorescent Probe with Sequential Two-Step ESIPT Activation Mechanism for Selective Hydrazine Detection and Multifunctional Applications. J. Hazard. Mater., 2025, doi.org/10.1016/j.jhazmat.2025.138388. (中科院一区,IF = 11.1, 第一作者&通讯作者)
(2) L. Wang, # H. Zou, # H. Ye, Y. Hai, H. Lu, J., Deng, L. You*. Photoswitchable Molecular Recognition Enabled by Dithienylethene-Mediated Structural Changes of Dynamic Covalent Hydrazone Bonds. CCS Chemistry, 2024, 6, 497-506. (中科院一区,IF = 11.2,共同第一作者).
(3) G. Jiang, L. Wang, H. Ye, H. Zou*, L. You*. Dynamic Covalent Reactions and Chirality Sensing with Diphenylethene Derived Hemiaminals. ChemPlusChem, 2023, e202300080. (中科院三区, IF = 3.21,通讯作者)
(4) S. Qin, H. Zou*, Y. Hai, L. You*. Aggregation-induced emission luminogens and tunable multicolor polymer networks modulated by dynamic covalent chemistry. Chin. Chem. Lett. 2022, 33, 3267-3271. (中科院一区,IF = 8.455,通讯作者)
(5) Z. She, H. Zou*, L. You*. Tuning the selectivity of amino acid recognition with dynamic covalent bond constrained fluorophores in aqueous media. Org. Biomol. Chem. 2022, 20, 6897-6904. (中科院三区,IF = 3.89,通讯作者)
(6) F. Sattar, Z. Feng, H. Zou*, H. Ye, Y. Zhang*, L. You*. Dynamic covalent bond constrained ureas for multimode fluorescence switching, thermally induced emission, and chemical signaling cascades. Org. Chem. Front. 2021, 8, 3760-3769. (中科院一区,IF = 5.456,通讯作者)
(7) I. Khan, J. Wang, H. Zou*, H. Ye, D. Zha, Y. Zhang*, L. You*. Noncovalent and dynamic covalent chemistry strategies for driving thermoresponsive phase transition with multistimuli and Controlled Encapsulation/Release. ACS Appl. Mater. Interfaces, 2020, 12, 2962−2973. (中科院二区,IF = 10.383,通讯作者)
(8) H. Zou,# Y. Hai,# H. Ye, L. You*. Dynamic covalent cwitches and communicating networks for tunable multicolor luminescent systems and vapor-responsive materials. J. Am. Chem. Soc. 2019, 141, 41, 16344-16353. (中科院一区,IF = 15.0,第一作者)
(9) Y. Hai,# H. Zou,# H. Ye, L. You*. Three switchable orthogonal dynamic covalent reactions and complex networks based on the control of dual reactivity. J. Org. Chem. 2018, 83, 9858−9869. (中科院二区,IF = 4.198,通讯作者)
(10) J. -J. Koh,# H. Zou,# S. Lin, H. Lin, R. T. Soh, F. H. Lim, W. Luan Koh, J. Li, R. Lakshminarayanan, C. Verma, D. T. H. Tan, D. Cao*, R. Beuerman*, S. Liu*; Nonpeptidic amphiphilic xanthone derivatives: structure-activity relationship and membrane-targeting properties , J. Med. Chem., 2016, 59, 171-193. (中科院一区,IF = 8.039,共同第一作者)
(11) H. Zou,# J.-J. Koh,# J. Li, S. Qiu, T. T. Aung, H. Lin, R. Lakshminarayanan, X. Dai, C. Tang, F. H. Lim, L. Zhou, A. L. Tan, C. Verma, D. T. H. Tan, H. S. O. Chan, P. Saraswathi, D. Cao*, S. Liu*, R. Beuerman*; Design and synthesis of amphiphilic xanthone-based, membrane-targeting antimicrobials with improved membrane selectivity, J. Med. Chem., 2013, 56, 2359-2373.(中科院一区,IF = 8.039,第一作者)
(12) K. Zhu, Z. Li, J. Cao, Y. Cao, J. Wang, S. Wang, L. Chen, H. Zhou, W. Huang, H. Zou, Q. Li, J. Mu, J. Song. Radio-Activated Selenium-Doped Janus Ag/Ag2SexSy Nanoparticles for Precise Cancer NIR-II Fluorescence Imaging and Radiosensitization Therapy. Adv. Sci. 2025,https://doi.org/10.1002/advs.202417828.(中科院一区,IF = 15.1)
(13) C. Yin,# H. Ye,# Y. Hai, H. Zou, L. You*. Aromatic-Carbonyl Interactions as an Emerging Type of Non-Covalent Interactions. Adv. Sci. 2024, 11, 2310337.(中科院一区,IF = 15.1)
(14) H. Lu, H. Ye, M. Zhang, Z. Liu, H. Zou, L. You*. Photoswitchable dynamic conjugate addition-elimination reactions as a tool for light-mediated click and clip chemistry. Nat. Commun. 2023, 14, 4015. (中科院一区,IF = 16.6)
(15) C. Yin, H. Lu, H. Ye, Z. Feng, H. Zou, M. Zhang and L. You*. Double n→π* Interactions with One Electron Donor: Structural and Mechanistic Insights. Org. Lett. 2023, 25, 1470−1475. (中科院一区,IF = 5.2)
(16) Q. Hu, Y. Liu, W. Li, Y. Wang, W. Liao, H. Zou, J. Li*, X. Huang*. Enhanced photocatalytic hydrogen evolution under visible-light using C, N Co-doped mesoporous TiO2 nanocrystals templated by ionic liquids. Chem. Eng. J. 2023, 451, 138670. (中科院一区,IF = 15.1)
(17) Y. Hai, H. Ye, Z. Li, H. Zou, H. Lu, and L. You*. Light-induced formation/scission of C-N, C-O, and C-S bonds enables switchable stability/degradability in covalent systems. J. Am. Chem. Soc. 2021, 143, 20368–20376. (中科院一区,IF = 15.0)
知识产权
(1) Hanxun Zou, Rajamani Lakshminarayanan, Lei Zhou, Chang chui Charles Tang, Jun-Jie Koh, Donald Tan, Chandra Verma, Roger W. Beuerman, Shouping Liu, Padmanabhan Saraswath. Derivatives of Xanthone Compounds. Pub. No.: WO/2013/036207; International Application No.: PCT/SG2012/ 000328.(已授权)
(2) 尤磊、邹汉勋、叶何波. 一种荧光开关及其制备方法、应用。 专利号:201910092023.2 (已授权)
(3) 尤磊、海宇、叶何波、邹汉勋、陆涵葳、李紫毅. 二噻吩乙烯内酯类化合物以及制备、光调控方法。专利号:202110184683.0(已授权)
(4) 尤磊、姜国山、海宇、邹汉勋、环链异构二苯乙烯荧光分子以及制备方法、应用。专利号:202110184903.X(已授权)
(5) 尤磊、海宇、叶何波、邹汉勋、陆涵葳、李紫毅. 一种芳基乙烯内酯类化合物及其制备方法、应用。专利号:202110471450.9
(6) 尤磊、邹汉勋、冯泽林、陆涵葳. 一种脲化合物其制备方法、应用。专利号:202110443727.7
(7) 尤磊、邹汉勋、张翼. 一种基于1,8-萘二甲酰亚胺的水溶性荧光探针及其制备方法和应用。专利号:201910246470.9
(8) 尤磊、陆涵葳、叶何波、章梅兰、邹汉勋. 一种2-(乙氧基亚甲基)1,3-二酮二噻吩乙烯衍生物及其制备方法和应用。专利号:202210948443.8
(9) 尤磊、陆涵葳、叶何波、章梅兰、邹汉勋。一种二噻吩乙烯1,3-二酮化合物及其制备方法、应用。专利号:202210947333.X
四、其它
个人荣誉
入选福建省高层次人才(C类)(2022年)